The world's largest airliner, with two decks of spacious cabins and room for 544 people in standard layout, was designed to challenge Boeing's legendary 747 but failed to take hold as airlines backed a new generation of smaller, more nimble jets.

Airbus said in a statement that the last A380 would be delivered in 2021.

Confirming a shake-up first reported by Reuters, it said Emirates - the largest A380 customer - had decided to reduce its orders for the iconic superjumbo and order a total of 70 of the smaller A350 and A330neo models.

The European company said it would enter talks with unions in coming weeks over the 3000-3500 jobs potentially affected.

Airbus will produce 17 more of the planes including 14 for Emirates and three for Japanese airline ANA.

As part of the restructuring, Emirates placed a new order for 40 A330-900neo jets and 30 A350-900 aircraft, partially restoring a purchase of A350 aircraft which it cancelled in 2014.

Emirates, which had built its global brand around the A380 and Boeing 777 and which also has 100 of the Airbus superjumbos in its fleet, said it was disappointed by the closure.

"Emirates has been a staunch supporter of the A380 since its very inception," said Emirates Chairman Sheikh Ahmed bin Saeed al-Maktoum.

"While we are disappointed to have to give up our order, and sad that the program could not be sustained, we accept that this is the reality of the situation," he added.

The A380 will remain a pillar of the Emirates fleet well into the 2030s, stated the airline.

Australian Associated Press