There were another six overseas acquired cases.

Ms Berejiklian said 50 of the 262 cases were active in the community.

A woman in her 80s, who was not vaccinated, was the sole fatality yesterday.

Ms Berejeklian said the Canterbury-Bankstown area was still the epicentre of the NSW outbreak.

Deputy police commissioner Gary Warboys Western Sydney was also the centre of police attention, with 171 of 454 infringement notices from south-western and north-western Sydney.

Ms Berejiklian said "more positively", the Georges River area was close to being taken out of the list of suburbs described as "areas of concern", and she urged as many people as possible to come forward for testing to give the experts "the confidence" to remove the listing.

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She said another four Sydney suburbs had been added to the existing eight Local Government Areas listed as areas of concern.

The conference heard there were 362 people in NSW hospitals, including 58 in intensive care, of whom 54 were unvaccinated.

The NSW update followed news from Queensland, where Cairns goes into lockdown from 4pm today, with the south-east Queensland lockdown ending at the same time, but with some restrictions remaining in place.

Also yesterday morning, Federal Minister Greg Hunt said the Therapeutic Goods Administration was about a fortnight away from approving a third vaccine for Australia - the Moderna mRNA inoculation developed in the USA.